Contact Us


  Probio LPL-137 (PF L-137) & Immunostimulatory response: 

Many lactic acid bacteria possess “immunostimulating activity.” However, the strength of the immunostimulating activity varies greatly depend on bacterial strains. LPL-137 (PFL-137) is characterized by an extremely high immunostimulating activity compared to other lactic acid bacteria. This powerful immunostimulating activity of LPL-137  (PF L-137) strongly supports your healthy life.

IFN-β is one of the cytokines that play an extremely important role in the host defense system. In a previous study in mice, oral administration of LPL-137 increased the production of IFN-β in blood. In the study on humans, we examined the effect of the intake of LPL-137 on the production of IFN-β. As a result, an increase in blood IFN-β concentration was observed in 75% of the subjects who took LPL-137.


Reference: Immunopharmacol Immunotoxicol 34: 893-899, 2012



IFN-β may have anti-inflammatory effects in rheumatoid arthritis (RA) patients through inhibition of the production of proinflammatory cytokines like TNF-α. Increased IFN-β production could represent a reactive attempt to inhibit the inflammatory cascade.


 Probio LPL-137 & Hyaluronic Acid (HA): 

Keratinocyte, which is a major component of the epidermis, maintains and repairs the tissues by the production of such substances as hyaluronic acid. It has been reported that this process is affected by immune cells in the skin, and if a wound occurs, the immune cells induce the production of hyaluronic acid from the keratinocytes to promote wound healing. Probio LPL-137 is expected to regulate hyaluronic acid production from keratinocytes if it acts on immune cells in the skin through its immunostimulating activity.

In this study, the effect of Probio LPL-137 on the production of hyaluronic acid from keratinocytes was examined by adding Probio LPL-137 to the epidermal cell culture that contain keratinocytes and immune cells. As a result, increases in the production of hyaluronic acid were observed by the addition of LPL-137.

Epidermal cells from mice were cultured for 7 days and the concentrations of hyaluronic acid in the culture medium were measured. LPL-137 was added to the culture medium at the concentration of 1 µg/ml.

The addition of LPL-137 increased the production of hyaluronic acid.


Cultured epidermal cells contain Langerhans cells and other immune cells specific for the epidermal tissues. LPL-137 may act on these cells to produce some factors that induce the production of hyaluronic acid from keratinocytes. It is also possible that LPL-137 directly acts on keratinocytes. In association with the observation, in vivo study shows that the moisture in the skin was kept in mice given LPL-137 orally. These results indicate that LPL-137 may enhance Hyaluronic Acid synthesis.


Probio LPL-137 improves quality of life (QOL): 

The term QOL (Quality of Life) is used to evaluate the level of mental and physical satisfaction with daily life (the purpose of life). QOL can be assessed objectively using QOL questionnaires those results can be quantified and analized statistically. Health-Related QOL is focused on one’s physical condition, and the questionnaire is narrowed down almost exclusively to health-related items. Since LPL-137 has immunostimulating activity and immune functions are related to the physical conditions, the changes in physical conditions in healthy subjects taken LPL-137 were evaluated using QOL questionnaires in this study. The results have revealed that LPL-137 improves the QOL, indicating that its immunostimulating activity can exert health promotion effects.

A double-blind randomized controlled trial was conducted in 60 healthy male and female volunteers aged 40 years or older. Thirty subjects received a capsule containing 10 mg of LPL-137 once daily for 12 weeks, and another set of 30 subjects received a capsule containing no LPL-137 once daily for 12 weeks. The efficacy of LPL-137 was evaluated by examining the immune functions and health-related QOL of the subjects at Weeks 0, 4, 8, and 12 after the beginning of the trial. Health-related QOL was assessed using a questionnaire with 26 items regarding physical and mental functions. The answer to each item was chosen from three options and then scored. Total QOL score was calculated by summing all the scores of the items. The degree of QOL improvement was defined as 100% if the total QOL score increased from the beginning of the study, 0% if unchanged, and ?100% if decreased. Mean value of the degree of QOL improvement in each group was calculated and compared.

In the LPL-137 group, a significant increase in the degree of QOL improvement was observed at Week 8 after the beginning of the study (P=0.049), and the increased level was maintained until Week 12 after the beginning of the study (P=0.092).

In the LPL-137 group, an enhancement of immune functions was observed from Week 4 after the intake, and the increased level was maintained until the end of the study. Such effects of LPL-137 on immunity may be responsible for the improvement of QOL, which was observed following to the increases in immune functions. The study demonstrated that LPL-137 not only increases the immune functions, but also improves the physical condition, suggesting that LPL-137 is a very useful food ingredient to maintain and improve our health.

Reference: J Nutr 136: 3069-3073, 2006



Heat‐killed Lactobacillus plantarum L‐137 (HK L‐137), an immunobiotic lactic acid bacterium, has been reported to enhance IFN‐γ production through induction of IL‐12. In this study, we investigated effects of HK L‐137 on skin moisturizing and production of hyaluronic acid (HA), extracellular matrix associated with the retention of skin moisture. Oral administration of HK L‐137 suppressed a loss of the water content in the stratum corneum in hairless mice. Treatment of primary epidermal cells with HK L‐137 increased HA production. Supernatant from immune cells stimulated by HK L‐137, which contained proinflammatory cytokines such as IL‐12, TNF‐α, and IFN‐γ, upregulated HA production and hyaluronan synthase 2 (HAS2) mRNA expression by BALB/3T3 fibroblasts via activation of transcription factor nuclear factor κB (NFκB). Although treatment of the supernatant with anti‐TNF‐α antibody (Ab) alone did not inhibit the HA production, combination of anti‐TNF‐α Ab with anti‐IFN‐γ Ab significantly inhibited the HA production. Thus, HK L‐137‐induced IFN‐γ plays a critical role in upregulated HA production in collaboration with TNF‐α. HK L‐137 may be useful for improvement of skin functions such as moisture retention by inducing HA production.



These statements have not been evaluated by official authority. This product is not intended to diagnose, treat, cure or prevent any disease.

This information is intended for use out of the US only. Some statements and claims enclosed may not be compliant with US regulations.